Thursday 16/03, at 13:30, in Amphi Holweck at ESPCI (10 rue Vauquelin).
We will have the pleasure to listen to Manon Molina, from DNA Script who will talk about her work on protein engineering for enzymatic DNA synthesis.
Title: Full circle @ DNA Script: Using enzymatically synthesized primers to engineer an enzyme required in enzymatic DNA synthesis
Abstract: Synthetic DNA is driving the biotech revolution and benchtop Enzymatic DNA Synthesis (EDS), such as being developed by DNA Script, will accelerate this revolution.
EDS has the advantages to be easily accessible avoiding the use of harsh chemical and to enable the synthesis of longer sequences compared to the traditional
phosphoramidite-based DNA synthesis. To meet the current requirements, EDS involves engineered enzymes for optimal performance on non-natural substrates and environments.
In this seminar, we will describe the enzyme engineering strategies used to engineer an enzyme for improved performance in the DNA script EDS technology and, coming full circle,
demonstrate how our benchtop EDS technology facilitated this effort.
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