Reactivity blueprints for bioinspired catalysis and chemistry
Pr. Marine Desage-El Murr, Omeca Lab, Institut de Chimie, Université de Strasbourg
Where : ENS, Salle des Actes
Marine Desage-El Murr is Professor of Chemistry at the University of Strasbourg where she leads the OMECA Lab involved in the development of catalytic methodologies and reactivities inspired by biological systems. After studying at the Ecole Supérieure de Chimie Physique et Electronique de Lyon (CPE Lyon), and the Ecole Nationale Supérieure de Chimie de Paris (ENSCP), she obtained her PhD in 2003 under the supervision of Dr Charles Mioskowski at the Commissariat à l’Energie Atomique (CEA Saclay). She was a post-doctoral research fellow at the University of Newcastle-upon-Tyne (UK) working in the groups of Prof. Roger J. Griffin and Prof. Bernard T. Golding. In 2007, she joined the Institut Parisien de Chimie Moléculaire (IPCM) at Université Pierre et Marie Curie (UPMC) as Associate Professor. In 2017, she was appointed Professor and group leader at the University of Strasbourg. Her research interests concern organometallic and coordination chemistry, bioinspired and redox catalysis, redox cofactors, and electron transfer. She is an active member of the SCF, now in the board of the bioinorganic chemistry group, and a member of the FrenchBIC network executive board. She is distinguished junior member of the French Chemical Society since 2021.
The exquisite and unrivalled efficiency of biological systems relies on the use of reactivity-enhancing tools to perform chemical reactions.[1] Among these tools, redox cofactors situated near metalloenzymatic active sites provide electron storage and release to assist the neighboring metal center in performing the reactions. Emulating such systems, the development of catalysts bearing redox-active ligands is a blossoming research field.[2] Our contributions to this field include transfer of CF3 groups,[3] stabilization of masked high-valent metallic oxidation states,[4] and transfer of nitrene and carbene moieties by redox-active copper complexes ligands. From a broader point of view, our efforts aim at cross-fertilizing the field of bioinspired catalysis with other reactivity-enhancing strategies such as spin catalysis,[5] entatic state reactivity[6] and ligand design.[7,8]
References
[1] A. Das, C. Hessin, Y. Ren, M. Desage-El Murr Chem. Soc. Rev. 2020, 49, 8840.
[2] a) P. J. Chirik, K. Wieghardt, Science, 2010, 327, 794; b) V. Lyaskovskyy, B. de Bruin, ACS Catal. 2012, 2, 270–279; c) D. L. J. Broere, R. Plessius, J. I. van der Vlugt, Chem. Soc. Rev. 2015, 44, 6886–6915.
[3] J. Jacquet, S. Blanchard, E. Derat, M. Desage-El Murr, L. Fensterbank, Chem. Sci. 2016, 7, 2030.
[4] J. Jacquet, P. Chaumont, G. Gontard, M. Orio, H. Vezin, S. Blanchard, M. Desage-El Murr, L. Fensterbank, Angew. Chem. Int. Ed. 2016, 55, 10712.
[5] Y. Ren, K. Cheaib, J. Jacquet, H. Vezin, L. Fensterbank, M. Orio, S. Blanchard, M. Desage-El Murr, Chem. Eur. J. 2018, 24, 5086.
[6] Y. Ren, J. Forté, K. Cheaib, N. Vanthuyne, L. Fensterbank, H. Vezin, M. Orio, S. Blanchard, M. Desage-El Murr, iScience, 2020, 23, 100955.
[7] A. Das, H. Jobelius, J. Schleinitz, S. Gamboa-Ramirez, G. Creste, G. Kervern, J. Raya, N. Le Breton, A. Guenet, Z. Boubegtiten- Fezoua, L. Grimaud, M. Orio, G. Rogez, P. Hellwig, S. Choua, S. Ferlay, M. Desage-El Murr Inorg. Chem. Front. 2021, 8, 5286. [8] A. Das, J. Schleinitz, L. Karmazin, B. Vincent, N. Le Breton, A. Guenet, S. Choua, L. Grimaud, M. Desage-El Murr Chem. Eur. J. 2022, 10.1002/chem.202200596.
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