Basic principles of molecilar spectroscopy
MH11ES.OAI
Written exam
The objective of the course is to present the usual analysis methods for organic molecules. The student should understand the fundamental bases of these methods and should be able to analyze different kinds of molecules. It is divided into three parts: NMR, mass spectrometry and molecular spectroscopy.
* Nuclear magnetic resonance spectroscopy:
– Analysis of 1H and 13C NMR spectra, determination of the covalent structure of organic molecules, NMR principles: spin concept, Zeeman effect, chemical shift, scalar coupling, spectrum recording techniques: 1H NMR: diastereoisotopy, 1st order and 2nd order spectra, … NMR 13C: 1D experiments, uncoupling, …
* Mass spectrometry:
– The basic principles of mass spectrometry and the characteristics of this spectrometry method (Molecular mass, average, isotopy, resolution, etc.)
– The different ionizations strategies and mass analyzers and their application in the study of more complex compounds.
– General fragmentation rules allowing the analysis of spectra of various organic compounds presenting the main functions encountered in organic chemistry.
* Molecular spectroscopy:
– Reminder of the fundamentals governing IR, UV-vis with a short introduction on Raman, and optical activity….
Acquisition of theoretical and practical knowledge of mass spectrometry (MS)and Nuclear Magnetic Resonance (NMR). In these lectures, the basic concepts of MS, spectroscopy and NMR are used to understand the applications of these two techniques to identify organic compounds. Exercise sessions will be used to become familiar with interpreting spectra of small molecules and macromolecules.
Teaching language: FR
Link: https://coursenligne.chimie-paristech.fr/enrol/index.php?id=16
