Pepijn Gerben Moerman (Eindhoven University of Technology) on Monday, November 16. The title of the talk is ‘Exploring local learning rules in DNA condensates’ and the abstract is provided below.
The seminar will take place in the Gulliver seminar room C1.62 at 11:30 and will be transmitted online at this link: https://visio.numerique.gouv.fr/vuf-njri-opc
The seminar will take place in the Gulliver seminar room C1.62 at 11:30 and will be transmitted online at this link: https://visio.numerique.gouv.fr/vuf-njri-opc
Exploring local learning rules in DNA condensates
Physical learning is a process by which materials acquire desired properties through exposure to examples, rather than through prior computational or experimental design. A central requirement is a local learning rule that modifies interactions in the system based on the examples. We asked how to realize such learning rules in condensates made of DNA nanostars. We show how the interaction strength between DNA nanostars can be updated based on their local environment using enzymatic reactions that covalently attach new DNA domains to the nanostars. The result is that the nanostars ‘remember’ their neighbors in a training phase and interact more strongly with neighbors of the same type in the retrieval phase. This interaction update rule is analogous to Hebbian learning – DNA nanostars that spend time together, grow to like each other – and enables the nanostars to form mixed condensates whose compositions reflect those present during training.