** Immune repertoires as self-organised evolving systems **, Aleksandra Walczak from LPENS.
This seminar will take place at the seminar room of Gulliver C1.62 at 11:30.
Abstract:
Living systems often attempt to calculate and predict the future state of the environment. Given the stochastic nature of many biological systems how is that possible? How is this system formed given the constraints of not recognising our own proteins? Assuming that the immune system follows a strategy that maximizes the long-term immune coverage and minimizes the short-term metabolic costs associated with somatic evolution, I will show how the system composition changes in response to current threats to prepare for future threats. Does host-pathogen co-evolution constrain the space viral trajectories? I will show that co-evolution between immune systems and viruses in a finite-dimensional antigenic space can be described by an antigenic wave pushed forward and canalized by host-pathogen interactions. This leads to a new emergent timescale, the persistence time of the wave’s direction in antigenic space, which can be much longer than the coalescence time of the viral population.
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