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DTSTART;TZID=Europe/Paris:20220210T110000
DTEND;TZID=Europe/Paris:20220210T140000
DTSTAMP:20220131T171655Z
CREATED:20220131T171655Z
LAST-MODIFIED:20220131T171655Z
UID:22828-1644490800-1644501600@www.chimieparistech.psl.eu
SUMMARY:Séminaire PG Chimie
DESCRIPTION:If you want to attend in person\, please fill the following registration form: \nhttps://docs.google.com/forms/d/e/1FAIpQLSc5kBzli29KO4_WoBpSoPNjgCejSfhZaLj9XX4gOD47d-Ssag/viewform?usp=sf_link \nA Sanitary Pass will be requested to enter the Amphitheater Jaurès \n \nThe seminar will be also accessible online at : https://us02web.zoom.us/j/81520058748?pwd=VXVkalBFR0Z3Rm5CeU54NnEwYzZlQT09 \n   \nThursday February 10th at 11 am  \nENS\, Salle Jaurès\, 29\, Rue d’Ulm\, 75005 Paris  \n \nAdventures in Metalloprotein Design:  \nEnhancing Cu Based Enzymatic Catalysis \nPr. Vincent L. Pecoraro  \nUniversity of Michigan\, Ann Arbor\, USA \nE-mail: vlpec@umich.edu \n  \n  \nVincent L. Pecoraro is the John T. Groves Collegiate Professor of Chemistry at the University of Michigan. He is an expert in bioinorganic and supramolecular chemistries\, having made substantial contributions to the understanding of photosynthetic water oxidation and vanadium biochemistry. In recent years he has been a leader in the field of metallaproptein desing and development of metallacrowns as biomolecular imaging agents. He served as an Associate Editor for Inorganic Chemistry for over 20 year and is a fellow of both the ACS and AAAS. \n  \nSolid Metalloproteins are critical cellular workhorses\, catalyzing difficult but essential transformations that are required for functions as diverse as energy generation\, metabolism\, or signaling. One of the greatest unanswered questions of metalloprotein chemistry is how protein structure influences the active site to afford a desired activity. The interplay between protein structure and catalytic activity of these enzymes forms the foundation of our work. The protein may influence both the first coordination sphere (ligand type\, number\, and relative geometry) as well as the outer coordination environment. While native metalloenzyme studies provide valuable insights\, interpretations of these systems are often inadequate because of the intricacy of the scaffold or the presence of multiple metal centers. Similarly\, small molecules can afford insight on reactions but are often limited by the solvent or the synthetic complexity required to append functional groups. For this reason\, we utilize an intermediate approach\, de novo designed -helical proteins\, which are easily synthesized\, water soluble and recapitulate native metalloprotein active sites well. These designed systems provide native-like folds that can be manipulated simply in order to limit the variables that are probed during our studies. With well-defined scaffolds\, one can employ both canonical and non-canonical sequences as well as non-coded amino acids to expand the chemical landscape that may be explored beyond that which is available in native systems. In this presentation\, studies focused on enhancing copper catalyzed nitrite reductase and superoxide dismutase activities will be discussed. We will show how systematic modifications to first coordination sphere ligands\, the immediate outer sphere environment as well as the helical pitch can lead to significant variations in observed activity.
URL:https://www.chimieparistech.psl.eu/evenement-agenda/seminaire-pg-chimie/
LOCATION:Ecole Normale Supérieure\, 29 rue d’Ulm\, Paris\, Ile de France\, 75005\, France
CATEGORIES:Séminaire
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DTSTART;TZID=Europe/Paris:20220210T140000
DTEND;TZID=Europe/Paris:20220210T170000
DTSTAMP:20220201T175114Z
CREATED:20220201T170525Z
LAST-MODIFIED:20220201T175114Z
UID:22835-1644501600-1644512400@www.chimieparistech.psl.eu
SUMMARY:Séminaire PG Chimie
DESCRIPTION:Thursday february 10th within the compulsory seminars for the M1 students at ICI Master of Chemistry at PSL University\, we will have the pleasure to listen to Prof. Didier Gourier who will develop the following topic « The proliferation of scientific misconducts: a plague for science and society in the 21st century ». This is of particular interest for all scientifics.\n\nPlease find a short abstract below.\n\n \n\nPr. Didier GOURIER \nChimie ParisTech\, PSL University\, CNRS\, IIRCP\, UMR8247\, 11 rue Pierre et Marie Curie\, 75005 Paris et Centre de Recherche et de Restauration des Musées de France C2RMF\, Palais du Louvre\n \nThursday 10th of february\n2pm\, Amphi Moissan at Chimie Paristech\, 11 rue Pierre et Marie Curie\, 75005 Paris\n\n\nTitre:  « The proliferation of scientific misconducts: a plague for science and society in the 21st century » \n\n \nRésumé: \nOver the last few decades\, there has been a worrying increase in misconduct in the research community. They generally result in the retraction of articles\, because of falsified or even invented results\, methodological bias\, plagiarism\, etc… Disseminated and amplified by the media and social networks\, these misconducts have negative impacts on society (health for example) but also induce a loss of confidence of citizens towards scientific research and researchers.  Through some recent and even current examples this presentation shows the consequences of such misconducts in our society.
URL:https://www.chimieparistech.psl.eu/evenement-agenda/seminaire-pg-chimie-3/
LOCATION:Amphi Moissan
CATEGORIES:Séminaire
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